DAS is the second most frequently met with mycotoxin in materials from water-damaged buildings (Tuomi, 2000)
DAS is the only Mycotoxin to have been in clinical trials as an anticancer drug (Anguidine). It was terminated in phase II because of its side-effects.
DAS is a member of group A trichothecenes, with T-2 Toxin,
This illustrates a difference between
the agricultural issues, and thoses linked to water damage : the mycotoxins can be the same, but produced by different fungi
The classical cereals containing DAS are Wheat, Oats, Barley, Maize, but also rice and solanaceae like Potatoes. The fungi species held responsible are Fusarium. But in water-damage DAS can be found associated with Aspergillus, Cladosporium, Penicillium, Mucor, and (not frequently) with Fusarium.
"diffuse disturbance of cerebral function and EEG anomalies";
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Percentage of samples positive for the named mycotoxin
Adapted from Tuomi T. et al., Mycotoxins in crude building materials from water-damaged buildings, Appl Envir Microbiol 2000, 66: 1899
Data on human toxicity of DAS are scarce. However phase I and II clinical trials of Anguidin demonstrate hematological and neurological toxicity:
In poultry DAS is 3 to 4 times (on LD 50) more toxic than HT-2 toxin ( Diaz, 2002, Poultry Sci., 81: 1492)
DAS is very frequently met with in animal feed