DNA damage control
Everyday 10,000 DNA molecules per cell BREAK (because of U.V., heat, low pH, hyperosmolarity, tobacco, and some therapies). If these cells reproduced, it would be a catastrophy.
Hence the 2 DNA Damage Control Systems :

- Halting the Cell Cycle
- DNA damage repair (DDR)
- DNA damage control
- Halting the cell cycle
- Cell cycle inhibitors
- DNA damage repair (DDR)
- DDR pathways
- DDR pathways inhibitors
New approaches in Biotech
- EGF
- VEGF
- AKT/ILGF
- Wnt
- Notch
- Ras
- RET
- DPP IV
- Protein kinases
& inhibitors
- NFKB pathway

How some monoclonals work
- abatacept
- basiliximab
- belatacept
- bevacizumab
- cetuximab
- dacluzimab
- eculizumab
- mapatumumab
- ocrelizumab
- panitumumab
- rituximab
-The Fc fragment