Predominant neurological features in the acute toxicity rodent model are quite related to the groups of signs seen in humans:
ataxia of a peculiar form, with cerebellar-type elements, nevertheless worsened by eye occlusion, and mild proprioceptive deficit.
Inhalation leads to direct passage into the brain, through the cribriform plate(like cocaine), and eventually through the sphenoidal sinus. Cerebrospinal fluid (CSF) can also be reached. DON (deoxynivalenol), after oral administration to sheep or pigs ( Prelusky 1990) is detected in the CSF. And it must be keep in mind that nasal absorption is much higher than oral.