IMPORTANCE OF NASAL ENTRY
LD 50 in mg/body weight
Young adult mice
Mature mice
Rats
Guinea
Pigs
0.24
0.94
4.50
0.05
10.00
1.00
1 - 2
0.40
CLINICALS
Stilted gait

Ataxia

Tremors

Lethargy
Using T-2 mycotoxin, Creasia et al. (1987, 1990) have shown that inhaled mycotoxin is far more lethal
than cutaneous, itself more lethal than systemic:
Predominant neurological features in the acute toxicity rodent model are quite related to the groups of signs seen in humans:
ataxia of a peculiar form, with cerebellar-type elements, nevertheless worsened by eye occlusion, and mild proprioceptive deficit.
Inhalation leads to direct passage into the brain, through the cribriform plate(like cocaine), and eventually through the sphenoidal sinus. Cerebrospinal fluid (CSF) can also be reached. DON (deoxynivalenol), after oral administration to sheep or pigs ( Prelusky 1990) is detected in the CSF. And it must be keep in mind that nasal absorption is much higher than oral.
Cutaneous
Route
of administration
Inhaled
Systemic (IP)
OTHER POLLUTIONS
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The tuning-fork, to chek for proprioceptive deficit