Mycotoxins can act, in various manners on gene transcription and expression
This is demontrated in mouse alveolar macrophages by Rand T.G., DiPenta J., Robbins C. and Miller J. D. in 2011
Adapted from Rand T.G. et al., Chemical-Biological interactions, 2011; 190: 139
This remarkable paper deals with 13 genes and 7 mycotoxins. We have selected 6 genes and 2 typical "damp building" mycotoxins : atranone ( produced by Stachybotrys ) and sterigmatocystin produced by Aspergillus, to show that different mycotoxins can have very different effects. This underlines the crucial importance, in any attempt to approach physiopathology of symptoms linked to water damage, of simultaneously analyzing the nature of the mycotoxins involved.
IL13 is a mediator of inflammation secreted by Th2 lymphocytes ( typically after allergen or irritant induced Th2 switch )
IL10 is an anti-inflammatory cytokine that can block Nfkappa B
IL15 is a cytokine which plays an important role in celiac disease (Malamut G. et al.J Clin Invest. 2010;120(6):2131–2143).
IL18 is a pro-inflammatory cytokine, and induces cell mediated immunity
IL1r1 is a key receptor of pro-inflammatory IL1
TNF is a pro-inflammatory cytokine, activating NF kappa B