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HEMATOPOIETIC PROGENITOR CELLS
BONE MARROW
Stromal cells
SDF1
CXCR4
Akt
AMD 3100
(plerixafor) inhibits the binding of SDF1 to CXCR4
CD 34 +/CD 38 -
progenitor
Cell
migration
Mobilized early stage peripheral blood stem cell leaving the bone marrow
Early stage progenitors carry in their membrane a receptor (CXCR4). Bone marrow stromal cells produce a factor , SDF1 (stromal derived factor), that tends to retain the progenitors.
Inhibiting the binding of SDF1 to early stage progenitors (bearing membrane antigen CD 34 but not CD 38), increases mobilization of these progenitors, which can then be extracted from peripheral blood by leukapheresis.(extracorporeal removal of leukocytes from the blood). These cells are then used to repopulate bone marrow of patients who have received therapies that are toxic for their bone marrow.
CXCR4 is a chemokine; each C represents a region with cysteine, X without, and R stands for "receptor"
Learn more about Akt, click here
also see :
- AKT/ILGF
- Wnt
- Notch
- Ras
- RET
- DPP IV
- Protein kinases
& inhibitors
- NFKB pathway

- DNA damage repair (DDR)
- DDR pathways
- DDR pathways inhibitors
- DNA damage control
- Halting the cell cycle
- Cell cycle inhibitors
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
DPP IV
EGF
EGFRvIII
GPCR
G proteins
ILGF
kinome
Kras
mannose P
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis