VEGF secretion increased by FGF, TGF, TNF, IL8
Regulation of embryogenesis,
skeletal growth, reproduction
- Facilitation of carcinogenesis
- Facilitation of vascular eye diseases (macular degeneration, diabetic retinopathy)
anti-KDR monoclonals:
CDP-791, pegylated di Fab
IMC-1121B, fully human IgG1