VEGF secretion increased by  FGF, TGF, TNF, IL8
HealthValue
VEGFR1
FLT1
VEGFR2
KDR
VEGFR3
PDGFbR
c-Kit
VEGF B
VEGF A
BEVACIZUMAB
Bevacizumab : anti VEGF A monoclonal antibody, click to see mode of action
VEGF C & D
lymphatics
VEGF gene
VEGF transcription increased by hypoxia
PDGF
SCF
Cancer cells proliferate
Endothelial cells
proliferate
Biotech approach to cancer : the VEGF route
Physiological role of VEGF
Regulation of embryogenesis,
skeletal growth, reproduction
Role of VEGF in disease
- Facilitation of carcinogenesis
- Facilitation of vascular eye diseases (macular degeneration, diabetic retinopathy)
VEGF vascular endothelial growth factor
VEGFR  VEGF receptor
TNF tumor necrosis factor
TK tyrosine kinase
TGF transforming growth factor
SCF stem cell factor
PDGF platelet derived growth factor
KDR kinase domain region
IL 8 Interleukin 8
FLT fetal liver TK
FGF fibroblast growth factor

A much more simple view : click here
DEFINITIONS
choisir la langue
back to home page
click to see the differences
Another approach : VEGF Trap
Visit the EGF system
anti-KDR monoclonals:
CDP-791, pegylated di Fab
IMC-1121B, fully human IgG1
Visit : Monoclonals
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
c-Met
DPP IV
EGF
EGFRvIII
GPCR
G proteins
HGF
ILGF
kinome
Kras
mannose P
MET
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt