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VEGF Trap (TM Eylea & Zaltrap) is built by the fusion to part of an immunoglobulin (an IgG1 Fc fragment), of 2 parts of the key VEGF receptors : Domain 2 of FLT1 (VEGF R 1) and Domain 3 of KDR (VEGF R 2).
This figure shows Domain 2 and 3 before they have been fused to an Fc fragment, as they are spontaneously in the extracellular part of the receptors, here represented on an endothelial cell.
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