VEGFA, the main isoform of VEGF, can be blocked by Bevacizumab, a monoclonal antibody, or by a "fusion protein", VEGF Trap, built using Fc fragments of IgG fused to VEGFR1 domain 2 and VEGFR2 domain 3. VEGF Trap is in clinical trials for cancer and approved for AMD.

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VEGF TRAP

(aflibercept, TM Zaltrap & Eylea)

see details of how VEGF TRAP makes use of FLT1 & KDR

You can block VEGF with a monoclonal antibody, Bevacizumab, or Ranibizumab

You can trap VEGF with a decoy construct, a "fusion protein", built with:

- elements of VEGF receptors:

  - Domain 2 of VEGFr1 and

  - Domain 3 of VEGFr2

added to

- fragments of immunoglobulin (Fc of IgG1)