VEGFA, the main isoform of VEGF, can be blocked by Bevacizumab, a monoclonal antibody, or by a "fusion protein", VEGF Trap, built using Fc fragments of IgG fused to VEGFR1 domain 2 and VEGFR2 domain 3. VEGF Trap is in clinical trials.
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Promenade guidée, suite
VEGF TRAP
(aflibercept)
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
see details of how VEGF TRAP makes use of FLT1 & KDR
water damage
akt-wnt
car-pollution
carbon dioxide
ctla4ig
EGFR
fumonisin
HSP
IgG1IgG2
mannose
Mycotoxcancer pathways
Molds & Brain
Mycotoxins
Notch
Ochratoxin
osteoclast
psoriasis
Multiple Sclerosis
sorafenib/sunitinib
cell cycle inhibitors
gaucher
sterigmatocystin
systemeNFkappaB
VEGF Trap
Wnt
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