APC adenomatous polyposis coli, DKK Dickkopf, Dvl disheveled, Fz frizzled, GSK glycogen synthase kinase, LRP low density lipoprotein receptor protein, OPG osteoprotegerin, RYK receptor related to tyrosine kinase, RANK-L receptor activator of nuclear factor kappa B-ligand, TCF T-cell specific transcription factor, WIF, Wnt inhibitor factor, Wnt wingless
WIF can be silenced in melanoma (# 1166), and is
downregulated in prostate, breast, NSCLC and GI cancers
Wnt dependent genes can be overexpressed in colorectal cancer (# 1270). High level correlates with prolonged overall survival. Hyperactivity could occur at early stages, and decreased expression at later stages. "This calls for caution in therapeutic strategy using Wnt inhibitors"
