Antisense medicines make use of "BASE PAIRING" :
among the four bases which form the backbone of nucleic acids (DNA & RNA), adenine has an affinity for thymine (or uracil), & guanine for cytosine.
Antisense medicines, of which only one (cidofovir) is commercialized as of today (for cytomegalovirus ocular infection in immunosuppressed patients), are mostly developed in oncology