Antisense medicines make use of the "BASE PAIRING"rule :
among the four bases which form the backbone of nucleic acids (DNA & RNA), adenine has an affinity for thymine (or uracil), & guanine for cytosine.
Antisense medicines, of which only one (cidofovir) was commercialized (for cytomegalovirus ocular infection in immunosuppressed patients), are mostly developed in oncology
An antisense medicine is built by linking bases chosen so as to block the corresponding bases of a specific sequence of DNA or of a messenger RNA
looking for a refresher on Adenine, Guanine etc..., click here
Blocks translation to protein