Certolizumab, pegylated Fab' fragment of humanized monoclonal
Certolizumab is devoid of an Fc fragment. Fc fragments are not the part of the monoclonal that recognizes the antigen (this is the role of Fab). Fc fragments are essential for lysis of target cells (that is one of the key activities of drugs like Rituximab). Recognizing the Ag and destroying cells are two completely different functions of monoclonals
