c-Met activation by HGF has 3 consequences in cancer :
- Endothelial cell proliferation
- Activation of key oncogenic pathways :
the Ras pathway,
the PI3K/STAT3 pathway, the b Catenin pathway
- Increased protease production and hence cell dissociation leading to metastasis
Abbreviations : ERK extracellular regulated kinase, Gab1 growth factor receptor bound protein 2 associated binder 1, GRB2 growth factor receptor bound protein 2, HGF hepatocyte growth factor, MAPK mitogen activated protein kinase, Mek MAP-ERK kinase, PI3K phosphoinositide kinase, STAT signal transducer and activator of transcription, Raf rat fibrosarcoma, Ras rat sarcoma
