- DNA damage repair (DDR)
- DDR pathways
- DDR pathways inhibitors
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Nucleus
DNA
Carcinogenic enzymatic
cascades
Stimulation of carcinogenic cascades
Carcinogenic membrane receptor
Classical chemotherapy attacks DNA
Blocking of carcinogenic cascades
Blocking of carcinogenic membrane receptors
New approaches in Biotech :
- Monoclonals
- EGF
- VEGF
Specific biotech anticancer drugs attack cancer cells essentially by blocking carcinogenic enzymatic cascades or carcinogenic membrane receptors, but respect DNA.
Classical anticancer chemotherapy, on the contrary, targets DNA.
Other biotech medicines are used in oncology, either to lessen some side-effects of chemotherapy (G-CSF is used for instance to fight neutropenia), which allows better tolerability of standard doses, or dose increase, or for their original anticancer effects (alpha interferon and interleukin 2 for instance)
CANCER & BIOTECH MEDICINES
CANCER CELL
- Cancer key figures
- Cell cycle inhibitors
- DNA repair inhibitors

Cytokines
Blocking a cytokine
- AKT/ILGF
- Wnt
- Notch
- Ras
- RET
- DPP IV
- Protein kinases
& inhibitors
- B lymphocytes

- DNA damage control
- Halting the cell cycle
- Cell cycle inhibitors
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MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
DPP IV
EGF
EGFRvIII
GPCR
G proteins
ILGF
kinome
Kras
mannose P
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Membrane receptor
Carcinogenic Mb receptor agonist