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HealthValue
Fields of HGF/c-Met involvement
HGF/c-Met and cancer
Cancer therapies addressing HGF/c-Met
Cancer therapies addressing HGF/c-Met
hz anti-HGF
AV299
Truncated c-Met
CGEN241
hu anti HGF
AMG 102
MetMab, one armed
Mab to c-Met
XL184, ARQ197, XL880, SGX523, PF-2,341,066, MP470
c-Met
HGF
c-Met
Ras
Grb2
Raf
Mek
MAPK
STAT3
Gab1
PI3K
b Catenin
activation
Increased
protease
production
Neoangiogenesis
Cell dissociation :
metastasis
Many new therapies, some of them in phase I or II clinical trials (May 07)
are targeting the HGF/c-Met
pathway :

- anti HGF monoclonal antibodies

- truncated variants of c-Met that act as decoys for HGF

- anti-c-Met monoclonals

- protein kinase inhibitors that block c-Met induced pathways (XL 184, ARQ197, XL880, SGX523, MP470,
PF2341066)
Abbreviations : ERK extracellular regulated kinase, Gab1 growth factor receptor bound protein 2 associated binder 1, GRB2 growth factor receptor bound protein 2, HGF hepatocyte growth factor, MAPK mitogen activated protein kinase, Mek MAP-ERK kinase, PI3K phosphoinositide kinase, STAT signal transducer and activator of transcription, Raf rat fibrosarcoma, Ras rat sarcoma
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
certolizumab
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
c-Met
DPP IV
EGF
EGFRvIII
GPCR
G proteins
HGF
ILGF
kinome
Kras
mannose P
MET
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Her3
In gefitinib/erlotinib resistant cells
c-Met can phosphorylate Her3,
leading to activation of the PI3K pathway. This constitutes an
escape route for cancer cells