derivesdanticorpsmonoclonauxfusi

HealthValue

Monoclonal antibody derivatives :

Fusion Proteins

Extracellular portion of membrane TNF (Tumor necrosis factor) receptor. TNF is an inflammatory factor which plays a key role in Rheumatoid arthritis,

Ankylosing Spondylitis,

Psoriasis, Crohn's disease

Etanercept is a fusion protein, obtained through fusion of the CH3, CH2 & hinge domains (Fc fragment) of an immunoglobulin, with part of a TNF receptor.

Etanercept is used in many therapies : it is a real TNF trap

TNF

ETANERCEPT

click to see the trap close

Alefacept is another fusion protein, between an immunoglobulin and the CD 58 receptor ( = LFA3, leucocyte function associated antigen 3). Alefacept is used in the treatment of Psoriasis.