Monoclonal antibody derivatives :
Extracellular portion of membrane TNF (Tumor necrosis factor) receptor. TNF is an inflammatory factor which plays a key role in Rheumatoid arthritis,
Etanercept is used in many therapies : it is a real TNF trap
Alefacept is another fusion protein, between an immunoglobulin and the CD 58 receptor ( = LFA3, leucocyte function associated antigen 3). Alefacept is used in the treatment of Psoriasis. Atacicept is a fusion protein that targets the B lymphocyte TACI receptor.