All the various repair pathways are essential for repairing the 10,000 DNA breaks that occur each day in each of our cells.
But these repair pathways present the inconvenience of counteracting anticancer tharapies such as radiotherapy and chemotherapy.
Inhibitors of the pathways are being developed for use in cancer patients. There are so many repair pathways, that this should not, usually, jeopardize the necessary permanent repair in normal cells