The Carcinogenesis maze
VEGFR
EGFR
HEDGEHOG
IGFR
DPP-IV
CD 26
RET
Ras
Notch
Wnt
HealthValue
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Abbreviations (often allude to where the gene was discovered : fruit fly, rat) :
DPP-IV dipeptidyl peptidase-IV, EGFR epithelial growth factor receptor, Hedgehog because
when the fruit fly bears this mutation its larvae are covered with spines , IGFR insulin like growth
factor receptor, Notch mutation inducing a notch in the wings of the fruit fly, RAS rat sarcoma,
RET rearranged during transfection, VEGFR vascular endothelial growth factor receptor,
Wnt wingless mutation of the fruit fly
Membrane receptors are the starting points of a maze of synergistic or antagonistic interwoven enzymatic cascades, which finally reach the intranuclear transcription control systems, themselves another maze, and from where carcinogenesis may rise.
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
c-Met
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
c-Met
DPP IV
EGF
EGFRvIII
GPCR
G proteins
HGF
ILGF
kinome
Kras
mannose P
MET
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt