Mannose 6 Phosphate (M6P) receptor
Endoplasmic reticulum cisternae
Lysosome
Golgi cisternae
DNA
mRNA
Therapeutic
lysosomal
enzymes
Endogenous lysosomal
enzymes
Like all proteins, lysosomal enzymes are coded for by DNA genes, then transcribed into mRNA, which is translated into proteins in the endoplasmic reticulum cisternae.
It is in these cisternae that the proteins are glycosylated and folded. Most* lysosomal enzymes are tagged with a Mannose 6 Phosphate recognition signal, which "addresses" them to the Golgi cisternae ( bearing specific receptors). The cisternae then bud to give birth to the lysosomes.
Therapeutic enzymes are also, in most cases, recognized by the M6P receptors
HealthValue
Biosynthesis of Lysosomes
* The glucocerebrosidase recognition signal does not seem to be M6P dependent.
For more info, click on the underlined links below :
Gaucher
Lysosomal diseases
Ceramides & Sphingolipids
Biosynthesis of lysosomes
Mannose 6 Phosphate & recognition of lysosomal enzymes
Lysosomes, cellular waste disposal facilities
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