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A monoclonal antibody has

2 heavy chains (H), and

2 light chains (L)

F (ab)

CH3

VL

VH

CL

CH1

CH2

Light chain L

Heavy chain H

The fragment which binds to

the antigen is called

F (ab) : fragment antigen binding

Each chain carries variable

domains (V), and constant domains (C)

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Monoclonal antibodies : chains, fragments & domains

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