Cerebral capillary
Normal lymphocyte
The lymphocyte exits from the capillary thanks to the integrin in its membrane




Normal brain
Neuron
Axon protected by its myelin sheath
Multiple Sclerosis
Activated lymphocyte
Myelin sheath altered  by immune processes linked to the activity of lymphocytes having crossed the blood-brain barrier
Beta Interferon, among other activities, inhibits activation and proliferation of lymphocytes
Treatment
by Beta
Interferon
Brain MRI showing MS "plaques" consequences of myelin alterations
Image from G. Rush (Alfred Hospital, Melbourne)
INTEGRIN
VCAM
which reacts with the VCAM '(vascular cell adhesion molecule) of the endothelial cell
Anti-integrin monoclonal: Natalizumab
An anti-integrin monoclonal
antibody
inhibits
the lymphocyte's
exit from the capillary, hence protecting the myelin sheaths
HealthValue
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MULTIPLE SCLEROSIS AND TREATMENTS
Treatment by antiintegrin antibody
How MS occurs
safety/efficacy is
regularly reviewed
(Please check corresponding pharmaceutical company sites, and Regulatory Agencies)
Monoclonals, About monoclonals, Diseases, Biotherapies
Cells/organelles, Pathways : Click for page map
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lymphocyte destructing agents
go to: MS Drugs
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