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H+ acid ions
Lysosomes pouring out enzymes
OSTEOCLAST
osteoporosis
Osteoclasts digest bone by secreting acid H+ ions and pouring out lysosomal enzymes 
OSTEOBLAST
The osteoblast has at least 3 roles : 1/ building bone,


by secreting a protein :
RANK ligand binds to the RANK membrane receptor of osteoclasts

RANK : receptor activator of nuclear factor kappa B
NFKB : nuclear factor kappa B
IKB : inhibitor of NFKB
Denosumab is a fully human IgG2 anti RANK ligand monoclonal antibody
More on NFkB: click
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RANK Ligand (RankL)
2/ activating osteoclasts
3/ secreting osteoprotegerin,
OPG,  a soluble receptor,
that binds RankL and inhibits bone resorption as a
decoy
nuclei
osteoclast activators
RANK
RANK LIGAND
Sclerostin
Wnt pathway
The Wnt pathway & Sclerostin are 2 other key osteoblast modulators
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CANCER
NFkappaB when in the nucleus, enhances translation of oncogenic genes
click here to understand the anti-cancer activity of denosumab