Osteoporosis is a decrease in bone mineral density, compromising its solidity, and increasing fracture risk.
Worldwide an estimated 1.5 million individuals suffer a fracture caused by bone disease annually. Around one third of these concern the hip.
20% of patients with a hip fracture die in the following year.50% of survivors are subject to considerable disability. Beyond the age of 50, one out of three women, one out of eight men, suffer from osteoporosis, and are at risk of developing a fracture.
Preventive and curative therapies of osteoporosis, beyond physical activity, smoking cessation, calcium, vitamin D, estrogens, can require drugs such as biphosphonates, calcitonin, parathormone-which may induce hypercalcemia, and a monoclonal antibody against RANK ligand : Denosumab