HealthValue
Bone is extremely alive, permanently nibbled at by osteoclasts, and rebuilt by osteoblasts.
Bone is not only the scaffolding of the body, but also the main reservoir of calcium, vital for cellular function and for blood coagulation.
OSTEOCLAST
OSTEOBLAST
75% of body weight
is borne by the hip
Osteoporosis is a decrease in bone mineral density, compromising its solidity, and increasing fracture risk.
Worldwide an estimated 1.5 million individuals suffer a fracture caused by bone disease annually. Around one third of these concern the hip.
20% of patients with a hip fracture die in the following year.50% of survivors are subject to considerable disability. Beyond the age of 50, one out of three women, one out of eight men, suffer from osteoporosis, and are at risk of developing a fracture.
Preventive and curative therapies of osteoporosis, beyond physical activity, smoking cessation, calcium, vitamin D, estrogens, can require drugs such as biphosphonates, calcitonin, parathormone-which may induce hypercalcemia, and a monoclonal antibody against RANK ligand : Denosumab
OSTEOPOROSIS
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MONOCLONALS
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ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
DPP IV
EGF
EGFRvIII
GPCR
G proteins
ILGF
kinome
Kras
mannose P
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt
related pages:
-osteoclast
-denosumab
-NFkB