PEROXISOMES

PEROXISOMES bud off directly from the endoplasmic reticulum

LYSOSOMES bud off fom the Golgi, after their content has trafficked through the endoplasmic reticulum

Peroxisomes are filled with enzymes particularily involved in :

- fatty acid metabolism

- cholesterol synthesis

- myelin synthesis

- purine catabolism

Some diseases are related to failures of peroxisome activity :

- X-linked adrenoleukodystrophy

- Zellweger syndrome

- Rhizomelic chondrodysplasia punctata

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PPAR

Peroxysome Proliferator Activated Receptors are nuclear receptor proteins involved in peroxisome production. PPAR agonists are used in the treatment of diabetes