choisir la langue

Families of protein kinases*

named according to the amino

acid they phosphorylate

Tyrosine kinases

Protein kinases*

Serine/Threonine kinases

Commercialized or studied inhibitors*

gefitinib, erlotinib, lapatinib

sunitinib, sorafenib, motesanib, pazopanib,

EGFR

VEGFR

Bcr-Abl

JAK

Ephrin

imatinib, dasatinib, AMN 107

CP 690550, PNU 156804

monoclonal, vaccines, XL 647

CDK

MAPK

ERK

JNK

p 38

Aurora kinases

Akt

mTOR

SNS 595, AT 7519

sorafenib

AS 601245, CEP 1347

VX 702

VX 680, SN 314, R 763

perifosine, INSM 18, RX 0201

rapamycin, temsirolimus,  everolimus

deforolimus

* non exhaustive list

Bcr-Abl Breakpoint cluster region-Abelson; CDK cyclin dependent kinases; ERK extracellular regulated kinases; JAK Janus kinases:

MAPK Mitogen activated protein kinases; mTOR molecular target of Rapamycin

Abbreviations :

Other Pages to visit :

- VEGF Pathway

- Anti EGFR monoclonals

- Anti VEGFR monoclonal

- AKT/ILGF/Wnt

- Notch/Hedgehog

- RAS

- DPP-IV

- Monoclonals

Take a look at :

- DNA damage control

- Halting the cell cycle

- Cell cycle inhibitors

- DNA damage repair (DDR)

- DDR pathways

- DDR pathways inhibitors

MONOCLONALS

abatacept

abciximab

adalimumab

alefacept

alemtuzumab

anti KDR

basiliximab

belatacept

bevacizumab

CDP 791

cetuximab

dacluzimab

denosumab

eculizumab

efalizumab

etanercept

IMC 1121

infliximab

ipilimumab

lumiliximab

Mab 806

mapatumumab

matuzumab

natalizumab

nimotuzumab

ocrelizumab

ofatumumab

omalizumab

palivizumab

panitumumab

ranibizumab

rituximab

ticilimumab

trastuzumab

VEGF Trap

zalutumumab

ABOUT MONOCLONALS

what is a monoclonal

chains & fragments

therapeutic fields

what are CDs

types of monoclonals

fusion proteins

cells to build monoclonals

making monoclonals

IgG1/IgG2 differences

F(ab) fragments

Fc fragment

Fc structure

Fc e receptors

Pathways

Adams

AKT

amino acids

complement

cancer pathways

cdk

DPP IV

EGF

EGFRvIII

GPCR

G proteins

ILGF

kinome

Kras

mannose P

NFKB

nucleotides

protein kinases

proteins

Ras

RET

sheddases

sunitinib/sorafenib

VEGF

Wnt

BioTherapies

antisense

cell therapy

exon skipping

gene therapy

hemopoietic prog.

monoclonals

protein kinases

recombinant prot.

stem cells

Cells/organelles

cell cycle

cells

chromosomes

DNA repair

exons

hemopoietic prog.

introns

lysosomes

mb. receptors

membrane CDs

mitochondria

proteasomes

stem cells

DISEASES

bird flu

cancer

diabetes

human growth hormone diseases

lysosomal diseases

mitochondrial diseases

multiple sclerosis

myelodysplastic sd

myopathies

osteoporosis

paroxysmal nocturnal hemoglobinuria

psoriasis

axitinib

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pathways