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Families of protein kinases*
named according to the amino
acid they phosphorylate
Tyrosine kinases
Protein kinases*
Serine/Threonine kinases
Commercialized or studied inhibitors*
gefitinib, erlotinib, lapatinib
sunitinib, sorafenib, motesanib, pazopanib,
EGFR
VEGFR
Bcr-Abl
JAK
Ephrin
imatinib, dasatinib, AMN 107
CP 690550, PNU 156804
monoclonal, vaccines, XL 647
CDK
MAPK
ERK
JNK
p 38
Akt
mTOR
SNS 595, AT 7519
sorafenib
AS 601245, CEP 1347
VX 702
VX 680, SN 314, R 763
perifosine, INSM 18, RX 0201
rapamycin, temsirolimuseverolimus
deforolimus
* non exhaustive list
Bcr-Abl Breakpoint cluster region-Abelson; CDK cyclin dependent kinases; ERK extracellular regulated kinases; JAK Janus kinases:
MAPK Mitogen activated protein kinases; mTOR molecular target of Rapamycin
Abbreviations :
axitinib