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PSORIASIS : Alefacept
Epidermis
Dermis
Keratinocyte accelerated proliferation
CD45RO+
lymphocyte
Immuno
competent
cell
from
human
IgG1
Fragment from
human
LFA3 (CD 58)
Alefacept is a fusion protein that consists of :
- the extracellular portion of human LFA3 (leukocyte function antigen 3, CD 58), that binds to the CD2 membrane receptor of T lymphocytes (especially the subset known as CD45RO+),
- linked to the Fc portion of human IgG1. This portion binds to a Fc receptor (CD16) on the membrane of immuno-competent cells, leading them to reduce activation & number of the particularly guilty subset of lymphocytes : CD45RO+.
Hence therapeutic value in psoriasis, as activated lymphocytes get rarer in the epidermis, decreasing inflammation and keratinocyte proliferation
Psoriasis main page
Psoriasis mechanism
Alefacept
Efalizumab
Etanercept
Infliximab
Promenade guidée, suite

BioTherapies
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ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
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what are CDs
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F(ab) fragments
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Wnt