psoriasisantiTNFengl

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PSORIASIS & anti TNF :

Infliximab, Etanercept

Keratinocyte accelerated proliferation

Epidermis

Dermis

Immuno

competent

cell

TNF

TNFR

TNFR

T

N

F

R

Cytokines

Leukocyte

TNF, tumor necrosis factor, produced by immuno competent cells, binds to TNF receptors (TNFR) and induces pro-inflammatory cytokine secretion (the NFkB pathway can be involved), increased cell migration to epidermis, activation of keratinocytes.

TNF

TNFR

TNFR

Fc

of IgG1

Etanercept is a fusion protein consisting of an extracellular part of a TNFR linked to the Fc portion of IgG1. Etanercept binds TNF & blocks its interaction with cell surface TNF receptors

Infliximab is a monoclonal antibody. It binds to

TNF, and inhibits binding of TNF to cell surface TNF

receptors

TNF

PSORIASIS

Psoriasis main page

Psoriasis mechanism

BioTherapies

hemopoietic prog.

protein kinases

recombinant prot.

ABOUT MONOCLONALS

what is a monoclonal

chains & fragments

therapeutic fields

types of monoclonals

fusion proteins

cells to build monoclonals

making monoclonals

IgG1/IgG2 differences

F(ab) fragments

DISEASES

human growth hormone diseases

lysosomal diseases

mitochondrial diseases

multiple sclerosis

myelodysplastic sd

paroxysmal nocturnal hemoglobinuria

Cells/organelles

hemopoietic prog.

Pathways

cancer pathways

protein kinases

sunitinib/sorafenib