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Epidermis
Dermis
Keratinocyte accelerated proliferation
ICAM
ICAM
CD11a
CD11a
CD11a
Lymphocyte
Efalizumab
The CD11a* membrane antigen is carried by T lymphocytes.
It allows them, by binding to an ICAM (intercellular adhesion molecule) of endothelial cells, to cross the capillary wall and enter the epidermis. There :
- CD11a stimulates the keratinocyte's ICAM,
- the activated lymphocytes also stimulate keratinocytes.
Hence the accelerated proliferation and maturation of keratinocytes : PSORIASIS.
Efalizumab is an anti CD11a monoclonal antibody, of therapeutic value in psoriasis.
PSORIASIS : Efalizumab
endothelial
cells
cytokines
*CD11a is a subunit of LFA1 (leukocyte function antigen 1), the other one is CD18
Lymphocyte
PSORIASIS

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