Roridins, a family of macrocyclic trichothecenes, mostly in houses, sometimes in animal feed
From animal feed,
From water damaged houses**
Adapted from: Polizzi V, Delmulle B, Adams N, Moretti A, Susca A, Picco AM, Rosseel Y, Kindt Ruben't, Bocxlaer JV, De Kimpe N, Van Peteghem C, De Saeger S. ; J. Environ. Monitoring. 2009, 11:1849-1858
Ethmoidal lamina cribrata
Osteolysis of posterior wall, sphenoid sinus is frequent in aged patients
In children before the age of 2, posterior wall of frontal sinus is
Roridin, introduced into the nasal cavity of rodents (Corps, Tox. Patho;. 2010, 38: 429), neurotoxic, can cause loss of olfactory sensory neurons, whose axons synapse with mitral neurons in the brain. The sense of smell is lost: ANOSMIA.
Apart from this retrograde axonal transporrt, roridin can reach the brain by penetrating the dura through osteolytic lesions of posterior walls of frontal and sphenoid sinuses.
Mycotoxins, like cocaine, can reach the brain, through the nasal sinuses
Roridin A is produced by Myrothecium; Many other Roridins are produced by Stachybotrys
* Roridin E, Bata A. Applied & Envir.Tox. 1985, 49:678