NF kappa B is a transcription activator.
It is present in many cells, and many species,
like the thousands of other transcription
activators, that control our lives.
NF kappa B acts on many genes,
activating cell differentiation & proliferation :
osteoclasts, lymphocytes, cancer, vascular,
bronchial, synovial and skin cells
The "activated" genes are transcribed into
mRNA, then into proteins.
NF kappa B is activated and migrates into the nucleus after degradation of
IkB protein (inhibitor of NFkB)
which confined it to the cytoplasm.
IkB degradation is first a phosphorylation by
NIK (NFkB inducing kinases), themselves activated by
enzymatic cascades induced by agonists of TLR, RANK, TNFR & IL1R.
Then the phosphorylated IKB binds to a protein, ubiquitine,& this complex is totally destroyed by organelles called : Proteasomes.
NIK induction inhibitor: denosumab, TLR antagonists.
Proteasome modulators: bortezomib, ONX 0912, CEP 18770, MLN 9708