NF kappa B system
NIK
IkB
NF
kB
Ubiquitine
NF
kB
Proteasome
Gene
DNA
Transcription
mRNA
Translation
Proteins activating proliferation of
RANK
TNFR
IL1R
NF kappa B is a transcription activator.
It is present in many cells, and many species,
like the thousands of other transcription
activators, that control our lives.
NF kappa B acts on many genes,
activating cell differentiation & proliferation :
osteoclasts, lymphocytes, cancer, vascular,
bronchial, synovial and skin cells
The "activated" genes are transcribed into
mRNA, then into proteins.
NF kappa B is activated and migrates into the nucleus after degradation of
IkB protein (inhibitor of NFkB)
which confined it to the cytoplasm.
IkB degradation is first a phosphorylation by
NIK (NFkB inducing kinases), themselves activated by
enzymatic cascades induced  by agonists of TLR, RANK, TNFR & IL1R.
Then the phosphorylated IKB binds to a protein, ubiquitine,& this complex is  totally destroyed by organelles called : Proteasomes.


TLR
osteoclasts, lymphocytes, cancer, vascular (VEGF, Hif1a ) , bronchial, synovial and skin cells

MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
DPP IV
EGF
EGFRvIII
GPCR
G proteins
ILGF
kinome
Kras
mannose P
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
related pages:
-osteoporosis
-osteoclast
-denosumab
-NFkB
Denosumab blocks Rank ligand, that could activate RANK. Rank gets NFkappaB into the nucleus, where it enhances translation of oncogenic genes
NIK induction inhibitor: denosumab, TLR antagonists.
Proteasome modulators: bortezomib, ONX 0912, CEP 18770, MLN 9708

INHIBITORS OF THE NFkappa B system: