Trichothecenes

HealthValue

Synthesized by around 300 fungal species, the more than 150 known trichothecenes, with a common skeleton, can be divided into 2 groups : "standard", and "macrocyclic"

The Trichothecene skeleton

Reactive double bond

V

Standard trichothecenes

Macrocyclic trichothecenes

Nivalenol

D.O.N.

Deoxynivalenol

Vomitoxin.

D.A.S.

Diacetoxyscirpenol

HT-2 Toxin, &

T-2 Toxin

Verrucarol

Roridin A

Verrucarin A

Satratoxin H

D

O

N

D

A

S

H

T

2

Toxin

N

I

V

A

L

E

N

O

L

T

2

Toxin

V

E

R

R

U

C

A

R

I

N

R

O

R

I

D

I

N

S

A

T

R

A

T

O

X

I

N

-

H

LD 50, mg/Kg

1/LD50

Relative

toxicities

of

trichothecenes

Macrocyclic trichothecenes are 10 to 100 times more toxic than standard trichothecenes

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OTHER POLLUTIONS

ATRANONES are somewhat akin to

Trichothecenes; They are highly reactive diterpenoids.

The name comes from Stachybotrys atra, now known as Stachybotrys chartarum

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