HealthValue
  TYPE MURINE CHIMERIC HUMANIZED "HUMAN"
  Human structures 0% 60-65% 90-95% 100%
  Examples anti CD3 basiliximab daclizumab adalimumab
      rituximab palivizumab panitumumab
      infliximab trastuzumab  
      cetuximab omalizumab  
        efalizumab  
        bevacizumab  
        alemtuzumab  
           
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Because of allergies to murine antibodies, recent therapeutic antibodies are more and more "human".
However even so-called  "human" monoclonals are manufactured as recombinant proteins, from human genes inserted into non-human cells (usually CHO)
adalimumab
anti TNF
alemtuzumab
anti CD 52
basiliximab
anti CD 25
bevacizumab
anti VEGF
cetuximab
anti EGFR
daclizumab
anti CD 25
efalizumab     anti CD 11a  
infliximab
anti TNF
omalizumab
anti IgE
palivizumab
anti VRS
rituximab
anti CD 20
trastuzumab
anti HER2
Types of monoclonal antibodies
what are all these CDs ?? click here to see
      panitumumab        anti EGFR
BioTherapies
antisense
cell therapy
exon skipping
gene therapy
hemopoietic prog.
monoclonals
protein kinases
recombinant prot.
stem cells
MONOCLONALS
abatacept
abciximab
adalimumab
alefacept
alemtuzumab
anti KDR
basiliximab
belatacept
bevacizumab
CDP 791
cetuximab
dacluzimab
denosumab
eculizumab
efalizumab
etanercept
IMC 1121
infliximab
ipilimumab
lumiliximab
Mab 806
mapatumumab
matuzumab
natalizumab
nimotuzumab
ocrelizumab
ofatumumab
omalizumab
palivizumab
panitumumab
ranibizumab
rituximab
ticilimumab
trastuzumab
VEGF Trap
zalutumumab
ABOUT MONOCLONALS
what is a monoclonal
chains & fragments
therapeutic fields
what are CDs
types of monoclonals
fusion proteins
cells to build monoclonals
making monoclonals
IgG1/IgG2 differences
F(ab) fragments
Fc fragment
Fc structure
Fc e receptors
DISEASES
bird flu
cancer
diabetes
human growth hormone diseases
lysosomal diseases
mitochondrial diseases
multiple sclerosis
myelodysplastic sd
myopathies
osteoporosis
paroxysmal nocturnal hemoglobinuria
psoriasis
Cells/organelles
cell cycle
cells
chromosomes
DNA repair
exons
hemopoietic prog.
introns
lysosomes
mb. receptors
membrane CDs
mitochondria
proteasomes
stem cells
Pathways
Adams
AKT
amino acids
complement
cancer pathways
cdk
DPP IV
EGF
EGFRvIII
GPCR
G proteins
ILGF
kinome
Kras
mannose P
NFKB
nucleotides
protein kinases
proteins
Ras
RET
sheddases
sunitinib/sorafenib
VEGF
Wnt