wntandtherapy

A fusion protein, F8CRDhFc,

made of part of the extracellular

domain of Fz, and of human Fc,

can block Wnt (# 5693)

- Epigallo-catechin-3-gallate can block beta catenin (# 1328)

- Avalon inhibitors can block beta catenin pathway

Expression of LRP & Fz receptors is down regulated in breast cancer cells by rosiglitazone

and troglitazone (#5635)

reference numbers such as # correspond to abstracts from the American Association for Cancer Research, April 2007

APC adenomatous polyposis coli, DKK Dickkopf, Dvl disheveled, Fz frizzled, GSK glycogen synthase kinase, HGF hepatocyte growth factor, LDRP low density lipoprotein receptor protein, MET mesenchymal epithelial transition receptor, OPG osteoprotegerin, RYK receptor related to tyrosine kinase, RANK-L receptor activator of nuclear factor kappa B-ligand, TCF T-cell specific transcription factor, WIF, Wnt inhibitor factor, Wnt wingless

NU206, an R-Spondin, is an agonist of Wnt, and could be useful for repair of damaged GI track tissues