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Wnt expands
stem cells
A fusion protein, F8CRDhFc,
made of part of the extracellular
domain of Fz, and of human Fc,
can block Wnt (# 5693)
Gene therapy for WIF can play a positive role in melanoma (# 1166)
- Epigallo-catechin-3-gallate can block beta catenin (# 1328), hence potential interest in RA
- Avalon inhibitors can block beta catenin pathway
Expression of LRP & Fz receptors is down regulated in breast cancer cells by rosiglitazone
and troglitazone (#5635)
reference numbers such as # correspond to abstracts from the American Association for Cancer Research, April 2007
Wnt & therapies
- Apterous drosophila
- Wnt pathways
- Wnt and Disease
- Wnt and therapies
- AKT/ILGF & Wnt
PHA665752, is a MET inhibitor that down regulates beta catenin
(# 2365)
APC adenomatous polyposis coli, DKK Dickkopf, Dvl disheveled, Fz frizzled, GSK glycogen synthase kinase, HGF hepatocyte growth factor, LDRP low density lipoprotein receptor protein, MET mesenchymal epithelial transition receptor, OPG osteoprotegerin, RYK receptor related to tyrosine kinase, RANK-L receptor activator of nuclear factor kappa B-ligand, TCF T-cell specific transcription factor, WIF, Wnt inhibitor factor, Wnt wingless
NU206, an R-Spondin, is an agonist of Wnt, and could be useful for repair of damaged GI track tissues